Presentation Title

Medical Art: Translating Cancer

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Date

4-30-2020

Description

Our understanding of neuroendocrine prostate cancer (NEPC) has assumed a new perspective in light of the recent advances in research. Although classical NEPC is rarely seen in the clinic, focal neuroendocrine trans-differentiation of prostate adenocarcinoma occurs in about 30% of advanced prostate cancer (PCa) cases, and represents a therapeutic challenge. To explain such complex processes to patients and family members, this artistic piece serves as an intermediary--communicating science to the public. Selected as the cover of the October issue of the Cancers Journal, it depicts the mechanisms that mediate neuroendocrine differentiation (NED) and the role of androgen deprivation therapy (ADT) as a key driver of this phenomenon. In this figure, I discuss the molecular, cellular, and therapeutic mediators of NED through color and hue, and emphasize the role of the tumor microenvironment (TME) in orchestrating the phenotype. In doing so, this illustration bridges any gaps in understanding the role of TME mediating NED. Further, the integration of art in scientific publications could provide us with valuable insights into the plasticity associated with the phenotype, and reveal potential therapeutic targets against this aggressive form of PCa.

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Apr 30th, 12:00 AM

Medical Art: Translating Cancer

Our understanding of neuroendocrine prostate cancer (NEPC) has assumed a new perspective in light of the recent advances in research. Although classical NEPC is rarely seen in the clinic, focal neuroendocrine trans-differentiation of prostate adenocarcinoma occurs in about 30% of advanced prostate cancer (PCa) cases, and represents a therapeutic challenge. To explain such complex processes to patients and family members, this artistic piece serves as an intermediary--communicating science to the public. Selected as the cover of the October issue of the Cancers Journal, it depicts the mechanisms that mediate neuroendocrine differentiation (NED) and the role of androgen deprivation therapy (ADT) as a key driver of this phenomenon. In this figure, I discuss the molecular, cellular, and therapeutic mediators of NED through color and hue, and emphasize the role of the tumor microenvironment (TME) in orchestrating the phenotype. In doing so, this illustration bridges any gaps in understanding the role of TME mediating NED. Further, the integration of art in scientific publications could provide us with valuable insights into the plasticity associated with the phenotype, and reveal potential therapeutic targets against this aggressive form of PCa.